Characterization of antinociception produced by glutamate microinjection in the nucleus tractus solitarius and the nucleus reticularis ventralis

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Characterization of antinociception produced by glutamate microinjection in the nucleus tractus solitarius and the nucleus reticularis ventralis.

Four experiments examined the role of the nucleus tractus solitarius (NTS) and subjacent nucleus reticularis ventralis (NRV) in the production of antinociception. Experiment 1 showed that microinjection of glutamate (50 nmol) into the caudal NTS resulted in inhibition of the tail-flick reflex, hypotension, and mild bradycardia, whereas microinjection of glutamate into the rostral NTS resulted o...

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The effect of nucleus tractus solitarius inactivation on blood pressure in diabetic rats

The role of nucleus tractus solitarius (NTS) in cardiovascular system regulation is controversial. On the other hand, the problem of hypertension in diabetic animals is the subject of many research programs. The aim of present study was to determine whether inactivation of NTS could affect blood pressure and heart rate in diabetic rats. To this end, stereptozotocin induced diabetic rats were an...

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The effect of nucleus tractus solitarius inactivation on blood pressure in diabetic rats

The role of nucleus tractus solitarius (NTS) in cardiovascular system regulation is controversial. On the other hand, the problem of hypertension in diabetic animals is the subject of many research programs. The aim of present study was to determine whether inactivation of NTS could affect blood pressure and heart rate in diabetic rats. To this end, stereptozotocin induced diabetic rats were an...

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The Effect of Nucleus Tractus Solitarius Nitric Oxidergic Neurons on Blood Pressure in Diabetic Rats

It has been shown that nitric oxide is synthesized in the central nervous system as well as in vascular endothelial cells. Recently, it was reported that nitric oxide was involved in central cardiovascular regulation, baroreflex modulation, and involved in a reciprocal release with excitatory amino acids in the nucleus tractus solitarii of rats. The purpose of the present study was to investiga...

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Inhibition of rho-kinase in the nucleus tractus solitarius enhances glutamate sensitivity in rats.

The Rho/Rho-kinase pathway in the central nervous system is involved in the maintenance of dendritic spines, which form the postsynaptic contact sites of excitatory synapses. Inhibition of the Rho-kinase pathway in neuron promotes dendritic spines or branches. In contrast, activation of the Rho/Rho-kinase pathway reduces dendritic spines or branches. Recent studies suggest that morphological ch...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1988

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.08-12-04675.1988